Chlorpropamide Pregnancy and Breastfeeding Warnings

Brand names: Diabinese

Chlorpropamide Pregnancy Warnings

Use is not recommended unless the benefit outweighs the risk to the fetus

US FDA pregnancy category: C

Comments:
-Most experts recommend insulin use during pregnancy to maintain blood glucose levels as close to normal as possible.
-Prolonged hypoglycemia has been reported in neonates born to mothers receiving a sulfonylurea at the time of delivery; if this drug is used during pregnancy, it should be discontinued at least 1 month before the expected delivery date and other therapies instituted to maintain blood glucose levels as close to normal as possible.

Animal reproductive studies have not been conducted with this long-acting sulfonylurea. Prolonged severe hypoglycemia of 4 to 10 days has been reported in neonates born to mothers receiving a sulfonylurea, particularly a long-acting sulfonylurea, at the time of delivery. There are no adequate and well controlled studies in pregnant women.

Abnormal blood glucose levels during pregnancy have been associated with a higher incidence of congenital abnormalities. If diet alone is not adequate to maintain guideline recommended blood glucose levels, most experts suggest insulin as the drug of choice during pregnancy.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

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Chlorpropamide Breastfeeding Warnings

Use is not recommended

Excreted into human milk: Yes

According to the manufacturer, an analysis of a composite of 2 samples of human breast milk obtained from 1 patient 5 hours after ingestion of a dose if 500 mg yielded a concentration of 5 mg/mL. Some experts feel this amount of drug in the breast milk is unlikely to affect a breastfed infant; however, shorter acting drugs are preferred to avoid drug accumulation. If a mother does breastfeed while on this drug, their breastfed infant's blood glucose should be monitored.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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