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Semaglutide for Diabetes, Type 2 User Reviews

Brand names: Ozempic, Wegovy, Rybelsus

Semaglutide has an average rating of 6.3 out of 10 from a total of 1067 reviews for the treatment of Diabetes, Type 2. 49% of reviewers reported a positive experience, while 27% reported a negative experience.

Semaglutide rating summary

6.3/10 average rating

1067 ratings from 1135 user reviews.

Compare all 162 medications used in the treatment of Diabetes, Type 2.

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Reviews for Semaglutide

  • Zell
  • Taken for 6 months to 1 year
  • March 29, 2021

Ozempic (semaglutide) "I started Ozempic 9 months ago. At the time, I was a little over 200 lbs and was taking 1000 mg of metformin daily. Metformin had worked for me for almost 20 years, so I didn't expect that it had suddenly stopped working. For 3 years, I gained weight even though I worked out, and I thought it was just my appetite out of control. One random day, I realized my metformin was the problem. I saw a new doctor who prescribed Ozempic. What a miracle! 9 months later, and I’m down 40 lbs, my A1C dropped from 8.1 to 5.6, and I have virtually no symptoms from the drug other than fullness. The symptoms in the beginning did not last long either. Nausea, headache, fatigue...all cleared up within a week or 2 each time my dose was increased. It can cause what feels like constipation, but for me, it’s just that I simply haven’t eaten enough. This drug feels too good to be true. I’m so pleased with my experience so far!"

10 / 10
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1144 Report
  • Stingie
  • Taken for less than 1 month
  • July 21, 2021

Ozempic (semaglutide) "I did one injection and have been ill since. I have had acid reflux, burping, vomiting, constipation, headache, and dizziness. I tried to eat small meals and drink plenty of water as directed by my physician, but I have been unable to hold anything down. Five days after my first injection, I'm off work, drinking Pedialyte, trying to get my strength back, and avoid being hospitalized. This is the worst that I have ever felt in my life."

1 / 10
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901 Report
  • Teresa
  • September 6, 2020

Ozempic (semaglutide) "I’ve been on Ozempic for 4 weeks. I am so glad that my doctor sat me down and told me what to expect. She also asked if I could handle it. She said that if you can make it through the 4th week, I promise it will get better. She was right. I was pretty sick the first two weeks. I learned that it had a lot to do with me trying to eat my normal intake of food. Once I started to catch a clue and make my portions smaller, I learned it would make me feel better. I could guarantee if I ate too much, I’d feel like crap. People aren’t kidding about the side effects. It’s real. But I made it and am now starting to feel better with each day. I’ve lost 18 pounds now and I’m amazed. Yes, it makes you sick, but if you keep trying to eat like you did, it will be worse. You have to start listening to your body. You can’t keep eating your same amounts and expect to lose weight."

10 / 10
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1064 Report

Frequently asked questions

  • MzGormo
  • Taken for 1 to 6 months
  • January 30, 2021

Ozempic (semaglutide) "Started on Ozempic in September 2020, starting weight 312 lbs (5’4”). I am type 2 diabetic and take 2550mg of Metformin daily. HbA1c was 79, sugar cravings, and blood sugar out of control. Started on 0.25 dose for a month. Quite bad stomach cramps and nausea for the first month. Went up to 0.5 dose in month 2, then 1.0 dose for month 3 and since. No. 1 tip - inject into your leg rather than around your belly. Once I changed to injecting in my leg, nausea and cramps disappeared overnight, and never came back. To maximize effectiveness, you can’t eat like you did before. I re-joined Weight Watchers in September. I have lost 80 lbs in 5 months, HbA1c dropped from 79 to 51 which is a normal type 2 level although the doc feels with more weight loss, it could go to normal levels. In Ireland, diabetes is classed as a long-term illness so all medications are covered by the government, so I don’t have to pay for this. Otherwise, it costs €195."

10 / 10
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766 Report
  • Doubt...
  • January 19, 2021

Ozempic (semaglutide) "I took one Ozempic injection at 0.25 and ended up at the ER 2 days later. I had horrible bloating. Burping smelled like eggs. Unstoppable vomiting and diarrhea. I ONLY TOOK ONE INJECTION and stopped the medicine. It has been 2 weeks and the medicine is still making me sick. I'm just wondering how long it takes to fully leave your system? I just want to feel human again. I was tested for pancreatitis but was okay, but the doctor said they will repeat labs soon. I DON'T RECOMMEND THIS MEDICATION TO ANYONE. PLEASE BE SAFE TAKING THIS MEDICATION."

1 / 10
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692 Report

Are you taking this medicine?

  • Mac
  • October 18, 2020

Ozempic (semaglutide) "Ozempic has caused me so much constipation!!! I know a side effect is diarrhea, but it does the complete OPPOSITE for me. A day or two after I take my injection, I have no bowel movements at all!! Every week I am forced to take a laxative. It has caused so many problems for me. Anyone else experienced severe constipation. So frustrated."

1 / 10
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645 Report
  • Kitkat
  • Taken for 1 to 6 months
  • July 20, 2021

Ozempic (semaglutide) "I'm a 54-year-old female whose A1C was 8.3 at the end of March. So, after 4 months on Ozempic, my A1C is now 6.3, and I've lost 34 lbs. Definitely curbs my appetite, and I have been logging my food. My side effects have been minimal - a little nausea in the beginning and constipation. This med has been a game-changer for me. My hope is that many others will have the same results I have."

10 / 10
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504 Report

More FAQ

  • Jarin
  • Taken for 1 to 6 months
  • August 30, 2020

Rybelsus (semaglutide) "This med Rybelsus is awesome. It has helped me bring my A1C down to 5.1 from a high of 9.7. I first started with the 3mg and am now on the 14mg. Been on this med since March and while I did experience some nausea and mild upset stomach, it went away after about a week. It has also helped me lose 50 lbs as well. I also take it with metformin. I should be the poster child for this drug... even though I'm 50."

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578 Report
  • Anon
  • Taken for 1 to 6 months
  • May 19, 2020

Ozempic (semaglutide) "I was terrified to take this after reading some of the reviews online, but I have to say I am so happy I started this drug. I've followed others' suggestions about injecting the drug into my upper thigh and not my abdomen. I was on a 0.25 dose for 4 weeks, then moved to 0.5, and that's what I currently take. My appetite has decreased SIGNIFICANTLY. I was addicted to eating junk foods, and I simply cannot eat them anymore; my stomach cannot handle them. I get full after eating one properly sized meal, and it keeps me going for most of the day, only having a snack like 1 apple in the evening. Side effects were mild for me; I had some constipation, but I started taking fiber supplements to help with that. I have been on the medication for 7 weeks now, and I'm down 10 lbs, and I feel great. Make sure your doctor gets you to increase the dose slowly, inject into your thigh, and be ready to make better dietary choices when starting this drug. I truly believe it saved me from morbid obesity."

10 / 10
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602 Report
  • Sane...
  • March 13, 2020

Ozempic (semaglutide) "After reading this, that junk in the fridge will go in the garbage. Do NOT put yourselves through this for weight loss and even diabetes. I mean seriously, which is worse? Pancreatitis? Thyroid cancer? Horrible gastro conditions? Injecting ourselves with this lizard juice can't be good for us. And, it’s beyond expensive to say the least. Pharmaceutical companies should be ashamed of themselves but that’s nothing new. This is totally off the charts. Just say no to drugs these drugs. Please be fair and unbiased and publish this comment, if you’re fair and unbiased!"

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620 Report
  • Conce...
  • Taken for 1 to 6 months
  • February 1, 2021

Ozempic (semaglutide) "I started Ozempic in late December at 0.25 injection. I also take 500mg metformin per day. Soon after I started Ozempic, I had decreased appetite and my sugars improved, but I had reflux, gas, bloating, nausea, and diarrhea. After 4 weeks, I started 0.50. 2 weeks in, I have bouts of painful constipation then diarrhea, nausea, bloating, gas, reflux, and cramping. I've almost vomited a few times. When I eat, it feels like the food just sits and sits, barely moving through my gut. My doctor wants me to stick with it, saying that these side effects usually improve, but it's been pretty miserable. I'm thinking I'm going to stop taking it. While Ozempic has been effective in regulating my sugars and losing weight, I don't think it's worth the suffering that I've been enduring on this medication. I understand that studies showed it causing thyroid cancer in mice, but no one knows if it causes thyroid cancer in humans. I don't want to be the guinea pig the drug makers use to find out it does."

5 / 10
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490 Report
  • Saucy
  • December 3, 2020

Ozempic (semaglutide) "Been on Ozempic since mid-April 2020. All side effects listed with the worst being chronic diarrhea. Nausea has been significant but has settled to occasionally. Trying to follow a more plant-based diet, I have lost today an official 60 pounds. I find the less meat I eat, the more energy I have, the better my blood sugars are as well. I am 53, so weight loss isn't impossible for us older ladies..."

7 / 10
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469 Report
  • jamison
  • Taken for 1 to 6 months
  • June 2, 2021

Ozempic (semaglutide) "I have been on 0.5 Ozempic for 2 months now. The nausea is no better. I vomit almost every day. Driving down the road and I begin to vomit. Almost caused me to wreck my car twice now. I've lost 30 pounds and feel terrible. My stomach hurts all the time and now my back. I do not urinate much at all even though I've increased water. Calling today and going off it. Losing weight is great, but not at the cost of feeling horrible every day."

5 / 10
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412 Report
  • Anne
  • December 28, 2020

Rybelsus (semaglutide) "I started taking Rybelsus at the beginning of August for weight loss. The biggest con for me is that it causes constipation and then usually diarrhea when I finally do go to the restroom. I have only had issues with nausea when I try to eat past the point of being comfortable. It is also important to try to eat something within an hour of taking the medication. When I first started on the medicine, I could only eat a few bites of food and then would feel extremely full and bloated and would have to stop. Now, it is 4 full months later, and I am on the 14mg, and I can continue to eat beyond a few bites without feeling miserable, but I try to stop as soon as I am full. I have, so far, lost 30 lbs with no exercise and have gone from a size 12/14 to a size 6/8. Diabetes does run in my family, so I am hoping continued use of this drug may help prevent the development of diabetes in the future."

10 / 10
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452 Report
  • Momo
  • Taken for 1 to 2 years
  • April 30, 2020

Ozempic (semaglutide) "I have been taking Ozempic for 16 months and have lost 80 lbs! I started at 0.25 and have moved up to 1. At first, I was terribly sick, but I took my time to adjust bit by bit while the dose was slowly raised, and now I don't feel sick at all from it. If you can hold on and push through (the push was hard, REALLY sick some days), it does get better. It has saved my life."

10 / 10
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453 Report
  • Margie
  • September 27, 2020

Ozempic (semaglutide) "I was put on Ozempic after taking Glimepiride for several years. I started on 0.25mg, then onto 1mg. I started having the nastiest burps ever, then diarrhea 3 to 4 times a day. After 3 months, I went to a gastroenterologist and was diagnosed with gastroparesis, a side effect of Ozempic. I have all the side effects - nasty, offensive-smelling burps, eye floaters in both eyes, bad diarrhea, stomach pain, and now this disease that has caused precancerous cells. Yes, my appetite has decreased, I have lost 15 lbs in 3 months, and my numbers are good. But it's not worth being sick every day. I just found out my daughter is going through the same exact thing. So, take it at your own risk."

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  • The...
  • Taken for less than 1 month
  • April 6, 2021

Rybelsus (semaglutide) "It’s been a week on Rybelsus 3mg. I feel pretty good (except for seasonal allergies). No nausea, no vomiting, no diarrhea, smaller appetite. I am prediabetic with BMI >30. I would like to lose 30 to 40 pounds. I think Rybelsus will help me. (Prior to taking Rybelsus, I was fasting (16-hour/8-hour) and exercising EVERY day and STILL gaining weight.) I think Rybelsus will help. I weigh daily, and I am beginning to see the numbers ever so slightly trend down. I am optimistic. I will start 7mg after 30 days. I hope to come back here and share my journey with you."

10 / 10
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323 Report
  • Will
  • Taken for 1 to 6 months
  • February 7, 2021

Ozempic (semaglutide) "Did the first 4 weeks of Ozempic at 0.25 had mild stomach issues. Nausea was come and go, really not consistent. Helped control my eating. Doctor said if you overeat or eat like you used to, you will throw up. There is no place for overeating but up. Didn't overeat, didn't have much issue. Took stool softener to keep things moving. At the 0.5 dose, ate less but had fewer side effects than my first dose. Glad I have started the med, it works."

10 / 10
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330 Report
  • JEano
  • Taken for 1 to 6 months
  • August 26, 2020

Ozempic (semaglutide) "I have been taking Ozempic for 4 months to reduce insulin resistance (caused by polycystic ovary syndrome). The medication has significantly reduced my appetite. I have had a few minor side effects - a stomach cramp here, an episode of diarrhea there...but nothing at all significant. My weight went from 151 (BMI 25.9) to 133 three months later (BMI 22.8). I honestly could not be happier."

10 / 10
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356 Report
  • 2Timer...
  • Taken for 1 to 6 months
  • January 18, 2021

Rybelsus (semaglutide) "For 2 years, my diabetes went out of control to the point that I started having some mental issues like brain fog. My doctor put me on 3mg Rybelsus. The first two weeks were a bit of a struggle, nothing I couldn't handle, just nausea and no desire to eat. A month in, my doctor took me up to 7mg. The first week at 7mg was the same, nausea, but after the week ended, it was gone. I still don't have a major appetite, which is excellent. My blood sugar is 104 at this moment. I've lost 24 pounds so far in 6 weeks. I love this stuff. I also feel much better, and I can actually think without the fog. I recommend it."

8 / 10
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299 Report
  • Maria...
  • Taken for 6 months to 1 year
  • February 1, 2021

Ozempic (semaglutide) "I started taking Ozempic in June 2020, initially lost 20 pounds by August. Total of 30 pounds so far, last 10 have been a lot slower. I went from 186 pounds to 156 pounds. A1c went from 6.5 to 5.6. Minimal side effects include occasional nausea and constipation. Started using Miralax, which has helped. Side effects I have experienced are worth the benefits. I consistently wake up with glucose levels in 80-90 range, never out of the green zone on a glucometer. I cannot overeat. If I do, I feel ill or get heartburn, so I have learned my lesson. I am really happy with this medication."

10 / 10
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292 Report
  • Lynn
  • December 22, 2020

Ozempic (semaglutide) "I took 1 dose of Ozempic and I have been sick ever since, diarrhea, vomiting, nausea, stomach cramps and a little dizziness. This is terrible, will never use again. Can someone tell me how long these symptoms last?"

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  • Snowc...
  • Taken for 6 months to 1 year
  • July 16, 2019

Ozempic (semaglutide) "Side effects are mild for me, but it really decreases your appetite. Initially, I could only tolerate fresh fruits and vegetables. I took this as an opportunity to change my lifestyle. I eat healthier and avoided sugary drinks. I lost a total of 40 lbs. in 6 months. A1C dropped from 7.3 to 5.4. Dress size dropped from 14 to size 4. I am no longer on daily insulin, BP meds, and cholesterol meds. All labs are normal. This medication is my lifesaver."

10 / 10
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316 Report
  • Gumbo
  • Taken for 1 to 6 months
  • February 28, 2020

Rybelsus (semaglutide) "I’ve been on Rybelsus since 1 December at a dose of 3 mg. January 1, I started 7mg. I don’t like taking medication and was scared of this medication due to other reviews I have read. I am very pleased with the outcome. I lost 5 lbs with very little exercise. My side effects were nausea and loss of appetite. Nausea only occurred when I ate junk food and sweets. A1c down from 7 to 6.2. Plus, I do not take any other meds for diabetes. Hope my review will help others. February 28."

10 / 10
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281 Report
  • Koobs
  • May 1, 2021

Rybelsus (semaglutide) "I have been taking rybelsus for 6 months. At first I was nauseous and had bad sulfur burps. But, it went away. My a1c is the best it's been in 9 years. I have had a hard go at treating my diabetes, as most other oral medications and daily infections, just made life harder. Now, my numbers are 6.7 and I have lost a significant amount of weight. 335lb to 285lb, with minimal effort. It definitely suppresses my appetite. I've read you can only lose a few pounds, but, I feel like a lucky one."

10 / 10
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210 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.